Endometriosis & Vitamin D

by endosolu

In a recent study it was shown conclusively that Vitamin D reserve are higher in women with endometriosis.

For the record my understanding is that the body (if healthy and in balance) will regulate the amount of Vitamin D in the system.

This balancing act is called ‘homeostasis’. If the body has all the nutrients it requires in most cases homeostasis is restored.

To get all the nutrients you need you really need to supplement (food is not that great anymore).  If your going to supplement choose organic food concentrates… that’s all we recommend on our natural endometriosis program.



BACKGROUND An immune-mediated defect in recognition and elimination of endometrial fragments refluxed in the peritoneal cavity has been hypothesized to play a crucial role in endometriosis development. Since vitamin D is an effective modulator of the immune system, we have hypothesized that the vitamin D status may have a role in the pathogenesis of endometriosis.

METHODS Women of reproductive age selected for surgery for gynecological indications were enrolled in this prospective cohort study. Serum levels of 25-hydroxyvitamin-D3, 1,25-dihydroxyvitamin-D3 and Ca2+ were assessed.

RESULTS Eighty-seven women with endometriosis and 53 controls were recruited. Mean (± SD) levels of 25-hydroxyvitamin-D3 in women with and without endometriosis were 24.9 ± 14.8 ng/ml and 20.4 ± 11.8, respectively (P = 0.05). The Odds Ratio (95% Confidence Interval) for endometriosis in patients with levels exceeding the 75th percentile of the serum distribution of the molecule (28.2 ng/ml) was 4.8 (1.7–13.5). A positive gradient according to the severity of the disease was also documented. A trend towards higher levels of 1,25-dihydroxyvitamin-D3and Ca2+ was observed in women with endometriosis, but differences did not reach statistical significance. As expected, serum concentrations of 25-hydroxyvitamin-D3 and 1,25-dihydroxyvitamin-D3, but not Ca2+, are influenced by the season (P < 0.001, P = 0.004, P = 0.57, respectively), while levels of the three molecules did not vary according to the phase of the menstrual cycle.

CONCLUSIONS Endometriosis is associated with higher serum levels of vitamin D.

For more info… http://humrep.oxfordjournals.org/content/22/8/2273.short

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