Immunobiology of endometriosis and why proteins are so important

by endosolu

The study below from my understanding is telling us that the body is producing the wrong amount of small cell signalling proteins than it needs to.

Can I suggest that you do your own research on how proteins in the body are synthesized… perhaps pay special attention to how healthy the liver needs to be… and that you need at least the nine essential (if your liver is healthy and able to synthesize the remaining needed… 22 in total).

FYI – part of our endometriosis program has the only natural product I know of that has all 22 amino acids in the ratios as found in nature.

Amino acid – Wikipedia, the free encyclopedia

Of the 22 standard amino acids, 9 are called essential amino acids because the human body cannot synthesize them from other compounds at the level needed  …


There are nine essential amino acids which humans must obtain from their diet in order to prevent protein-energy malnutrition. They are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine, andhistidine.[2][4] There are five dispensable amino acids which humans are able to synthesize in the body. These five are alanine, aspartic acid, asparagine, glutamic acid and serine.[2] There are six conditionally essential amino acids whose synthesis can be limited under special pathophysiological conditions, such as prematurity in the infant or individuals in severe catabolic distress.[2] These six are arginine, cysteine, glycine, glutamine, proline andtyrosine.[2]

Humans need the essential amino acids in certain ratios. Some protein sources contain amino acids in a more or less ‘complete’ sense. This has given rise to various ranking systems for protein sources, as described in the article.


Objective: To provide a review of the humoral and cellular immunology of endometriosis and to discuss the rationale for future approaches to diagnosis and treatment.

Design: Literature survey.

Result(s): Defective immuno surveillance in women who are destined to develop endometriosis may allow for the survival of ectopic endometrial tissue. The evidence includes endometrial cell resistance to apoptosis, perhaps through the secretion of proteins that interfere with implant recognition and/or FasL expression by stromal cells, inducing apoptosis of Fas-bearing immune cells. Although the immune response may be defective, aspects of it clearly are enhanced in endometriosis, as is seen by the generalized polyclonal B-cell autoimmune activation and secretion of immune proteins. Several cytokines, chemokines, and growth factors (including vascular growth factors) are increased in women with endometriosis.

Conclusion(s): A complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. Proinflammatory proteins from endometriotic lesions and associated immune cells contribute to the enhanced inflammatory reaction associated with endometriosis that subserves the survival of these lesions instead of leading to their demise.

Lebovic, Dan I., Michael D. Mueller, and Robert N. Taylor. “Immunobiology of endometriosis.” Fertility and sterility 75.1 (2001): 1-10.

Previous post:

Next post: